Thermo Fisher Scientific PTBP1 Polyclonal Antibody
PTBP1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. WB 및 IHC(P) 적용 가능. 고순도 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적. RNA 결합 hnRNP 단백질 연구에 적합.
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Thermo Fisher Scientific PTBP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide DGIVPDIAVGTKR (Human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2176393 |
Product Specific Information
- Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25642-PEP).
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and influence pre-mRNA processing, mRNA metabolism, and transport.
While all hnRNPs are present in the nucleus, some shuttle between the nucleus and cytoplasm. The encoded protein has four quasi-RNA recognition motif (RRM) domains that bind RNAs. It binds intronic polypyrimidine tracts required for pre-mRNA splicing and acts via the ubiquitin-proteasome pathway. It may promote U2 snRNP binding to pre-mRNAs.
Localized in the nucleoplasm and perinucleolar structure. Alternative splicing generates different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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