Thermo Fisher Scientific Aromatase Recombinant Rabbit Monoclonal Antibody (5C5N7)
Aromatase (CYP19A1) 단백질을 인식하는 토끼 유래 재조합 단일클론 항체. Western blot, IHC, ICC, ELISA에 적합하며, 고순도의 Affinity 정제 제품. 인간 시료 반응성, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:800–1:8,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5C5N7 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human Aromatase (CYP19A1) (P11511) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.75 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911796 |
Product Specific Information
- Positive test controls include: U-87MG
- Immunogen sequence:
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum and catalyzes the final steps of estrogen biosynthesis through three successive hydroxylations of the A ring of androgens.
Mutations in this gene can result in altered aromatase activity, with phenotypes suggesting that estrogen functions both as a sex steroid hormone and as a regulator of growth and differentiation.
Two transcript variants are known to be expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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