Thermo Fisher Scientific ISG15 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MGWDLTVKML AGNEFQVSLS SSMSVSELKA QITQKIGVHA FQQRLAVHPS GVALQDRVPL ASQGLGPGST VLLVVDKCDE PLSILVRNNK GRSSTYEVRL TQTVAHLKQQ VSGLEGVQDD LFWLTFEGKP LEDQLPLGEY GLKPLSTVFM NLRLRGGGTE PGGRS

Target Information

Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MHC-restricted cytotoxicity.
Synthesis is stimulated by IFN-alpha, IFN-beta, or IFN-omega, but not IFN-gamma. ISG15 expression is also induced by overexpression of interferon regulatory factors and by influenza B virus.
ISG15 is secreted by monocyte, T-lymphocyte, B-lymphocyte, human fibroblast, and epithelial cell lines. It enhances NK cell proliferation, augments non-MHC-restricted cytotoxicity, and induces IFN-gamma from T cells, identifying ISG15 as a cytokine cascade member.
Mutations affecting the gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.