Thermo Fisher Scientific C4BPB Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: Jurkat, Raji, K562, BCL-1
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide-linked, multimeric protein composed of seven alpha chains and one beta chain. It functions as a cofactor for C3beta inactivator in the cleavage of C3beta and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I.
Certain Streptococcal strains expressing Ig-binding cell surface molecules (members of the M protein family) can bind to overlapping C4beta binding sites in C4BP, interfering with the classical pathway of complement activation. This bacterial interaction may downregulate complement activation in the bacterial microenvironment, reducing bacterial opsonization and phagocytosis.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.