Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI1E2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2; T-cell immunoglobulin and mucin domain-containing-3) is a 281-amino-acid, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like extracellular domain, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation, autoimmune disease induction, and regulation of Th1-mediated immune responses, contributing to immune tolerance.
Pathological relevance includes roles in experimental autoimmune encephalomyelitis (EAE) and autoimmune disease severity modulation in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.