Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI1E2), TrueMAB
HAVCR2(TIM-3) 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot과 유세포분석에 적합. 동결건조 형태로 공급되며 PBS 버퍼에 8% 트레할로스 포함. 인간 시료 반응성, 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E2 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2; T-cell immunoglobulin and mucin domain-containing-3) is a 281-amino-acid, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like extracellular domain, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation, autoimmune disease induction, and regulation of Th1-mediated immune responses, contributing to immune tolerance.
Pathological relevance includes roles in experimental autoimmune encephalomyelitis (EAE) and autoimmune disease severity modulation in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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