Thermo Fisher Scientific ASIC1 Polyclonal Antibody
Thermo Fisher Scientific의 ASIC1 Polyclonal Antibody는 인간 ASIC1 단백질을 인식하는 토끼 유래 다클론 항체로, Western blot 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C 단기 보관 및 -20°C 장기 보관이 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 15–377 of Human ASIC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545717 |
Product Specific Information
- Recommended positive control: U87-MG
- Predicted reactivity: Mouse (97%), Rat (97%), Rhesus Monkey (100%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels containing intracellular N- and C-termini, two hydrophobic transmembrane regions, and a large extracellular loop with conserved cysteine residues.
ASIC1 is expressed in most brain neurons and functions as a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. It is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, hippocampus, cerebellum, and other brain regions.
Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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