Thermo Fisher Scientific GTF3C3 Polyclonal Antibody
Thermo Fisher Scientific의 GTF3C3 Polyclonal Antibody는 인간, 마우스 및 비인간 영장류 시료에 반응하는 rabbit IgG 항체입니다. Western blot과 면역세포화학에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA5103259
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GTF3C3 (Accession Q9Y5Q9), corresponding to amino acid residues E27–G77 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852621 |
Product Specific Information
Antibody detects endogenous levels of total TF3C3.
Target Information
RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors in vivo. To maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex includes TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63, which are overexpressed in malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may play a key role in deregulation of malignant cells.
The TFIIIB complex includes TBP, BRF1, and TFIIIB, which are upregulated in transformed cells. In many carcinomas, tumor suppressors RB and p53 are inactivated, reducing their ability to bind and inactivate TFIIIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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