Thermo Fisher Scientific STAT4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:100–400

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–200

Product Specifications

Target Information

STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homo- or heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.

STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is essential for T-cell independent induction of IFN-gamma and the development of Th1 responses against intracellular pathogens. STAT4-deficient mice show impaired IL-12–mediated Th1 development and enhanced Th2 responses. In viral infections, IFN-α/β activation of STAT4 is required for IFN-γ production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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