Thermo Fisher Scientific SIGLEC7 Polyclonal Antibody
Thermo Fisher Scientific의 SIGLEC7 폴리클로날 항체는 인간 시료에 반응하며, Western Blot, IHC, ICC/IF에 사용 가능합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, PBS 및 50% 글리세롤 용액 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Sialic Acid Binding Ig Like Lectin 7 (amino acid range 18–353 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903912 |
Target Information
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide, and disialyl GalNAc lactotetraoslylceramide).
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
In the immune response, may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Mediates inhibition of natural killer cell cytotoxicity and may play a role in hemopoiesis.
Inhibits differentiation of CD34+ precursors toward myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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