Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (OTI2C11), TrueMAB
인간 CD20(MS4A1)을 표적으로 하는 Mouse IgG2b 단클론 항체입니다. Western blot 및 파라핀 절편 IHC에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS, BSA, 글리세롤 기반 용액으로 -20°C 보관이 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C11 |
| Immunogen | Full length human recombinant protein of human MS4A1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation. It is expressed on mature and most malignant B cells, as well as on a subset of T lymphocytes and follicular dendritic cells. CD20 expression is synchronous with surface IgM and regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. It associates with lipid rafts, with the intensity of association depending on extracellular triggers and BCR aggregation. CD20 remains on the cell surface after receptor ligation and is a key target for antibody-mediated B-cell depletion therapies. Dysfunction of CD20 is linked to Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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