Thermo Fisher Scientific CCM2 Polyclonal Antibody
CCM2 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, 인간 및 흰쥐에 반응합니다. WB, ICC/IF, Flow Cytometry에 사용 가능하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KGEKSRDKKAHEK) corresponding to internal amino acids of CCM2 (aa 23–36) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979777 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
CCM2 encodes a scaffold protein involved in the stress-activated p38 MAPK signaling cascade.
It interacts with SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) to promote RhoA degradation.
This protein is essential for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.
Mutations in CCM2 are associated with cerebral cavernous malformations.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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