Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine hydroxylase를 표적하는 goat polyclonal antibody로, WB, IHC, ICC에 사용 가능. 인간 반응성 및 canine, rat 교차 반응 예측. 고순도 액상 형태로 안정적이며 신경전달물질 합성 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (VQDELDTLAHAL) corresponding to the C-terminus amino acids of TH (aa 513–525) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979872 |
Product Specific Information
- This antibody is predicted to react with canine and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate enzymatic activity.
In humans, four TH mRNA splice variants (hTH1–hTH4) exist, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
Dysregulation of TH is associated with several neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and hypertension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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