Thermo Fisher Scientific GPX1 Recombinant Rabbit Monoclonal Antibody (1H10F7)

Applications and Tested Dilutions

Product Specifications

Target Information

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins that catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. Several isoforms differ in primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme and the first of the GPx family to be discovered. GPx2, or gastrointestinal GPx (GI-GPx), is expressed only in the gastrointestinal epithelium. Extracellular plasma GPx (GPx3) is mainly expressed by the kidney and released into the bloodstream. Phospholipid hydroperoxide GPx4 (PH-GPx) is expressed in most tissues and reduces hydroperoxides integrated in membranes and lipids. Most mammalian GPx family members, except for the Cys-containing GPx3 and epididymis-specific GPx5 isoforms, possess selenocysteine at the active site.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.