Thermo Fisher Scientific PUF60 Polyclonal Antibody
Thermo Fisher Scientific의 PUF60 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. Western blot, ELISA, IP 등 다양한 응용에 적합하며, 고순도 Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적입니다.
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Thermo Fisher Scientific PUF60 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 243–542 of human PUF60 (NP_055096.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914601 |
Product Specific Information
- Positive test controls: THP-1, A-549, Mouse brain, Mouse thymus, Mouse spleen, Rat lung, Rat liver, Rat heart
- Target localization: Nucleus
Immunogen sequence:
DPTTGKHKGY GFIEYEKAQS SQDAVSSMNL FDLGGQYLRV GKAVTPPMPL LTPATPGGLP PAAAVAAAAA TAKITAQEAV AGAAVLGTLG TPGLVSPALT LAQPLGTLPQ AVMAAQAPGV ITGVTPARPP IPVTIPSVGV VNPILASPPT LGLLEPKKEK EEEELFPESE RPEMLSEQEH MSISGSSARH MVMQKLLRKQ ESTVMVLRNM VDPKDIDDDL EGEVTEECGK FGAVNRVIIY QEKQGEEEDA EIIVKIFVEF SIASETHKAI QALNGRWFAG RKVVAEVYDQ ERFDNSDLSA
Target Information
PUF60 encodes a Ro RNP-binding protein that interacts with Ro RNPs, representing a gain of function for these complexes. It forms a ternary complex with FUSE and FUSE-binding protein, repressing c-myc reporter activity via FUSE. PUF60 also targets transcription factor IIH and inhibits activated transcription. This gene is implicated in xeroderma pigmentosum disorder and has two alternatively spliced transcript variants encoding different isoforms, with evidence of multiple polyadenylation sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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