Thermo Fisher Scientific BST-2 Polyclonal Antibody
Human BST-2 단백질을 인식하는 Goat Polyclonal Antibody로 Western blot에 적합. 합성 펩타이드(aa 73-84)를 면역원으로 사용. 0.5 mg/mL 농도의 액상 형태이며, TBS(pH 7.3)와 0.5% BSA 포함. -20°C에서 보관하며 동결·해동 반복은 피해야 함.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ELTEAQKGFQD) corresponding to the internal amino acids of BST2 (aa 73–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11006612 |
Product Specific Information
This antibody has been tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in the development and growth of B-cells.
The surface expression of BST2 on fibroblast cell lines facilitates stromal cell-dependent growth of DW34, a pre-B-cell line.
BST2 is highly expressed during B-cell development (from pro-B precursors to plasma cells), T-cells, monocytes, NK cells, DCs, and myeloma cells.
Research studies indicate BST2 functions as an inhibitor of retrovirus release from human cells, with activity antagonized by the HIV-1 accessory protein Vpu.
BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments; its depletion abolishes the viral requirement for Vpu in virus release.
This suggests a potential therapeutic strategy for HIV/AIDS treatment. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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