Thermo Fisher Scientific Phospho-ASK1 (Ser967) Polyclonal Antibody
Phospho-ASK1 (Ser967) 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응하며 Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능합니다. Protein A로 정제된 액상 형태로, -20°C에서 보관합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human ASK1 around the phosphorylation site of Ser967 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated in response to various extracellular stimuli, including cytokines, growth factors, and environmental stresses. ASK1 (apoptosis signal-regulating kinase 1) activates two MAPKK subgroups, MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through interactions with TRAF family members and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death, while a catalytically inactive form inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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