Thermo Fisher Scientific Phospho-Chk1 (Ser345) Polyclonal Antibody
Chk1 단백질의 Ser345 인산화 형태를 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 ELISA에 적합. Human, Mouse, Rat에 반응하며, 액상 형태로 1.27 mg/mL 농도 제공. DNA 손상 반응 연구 및 세포주기 조절 단백질 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:100–1:500
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphorylated peptide around S345 of human Chk1 (NP_001265.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914862 |
Product Specific Information
- Positive test controls: HT-29, HepG2, C6
- Localization: Cytoplasm, Nucleus, Centrosome, Cytoskeleton, Microtubule organizing center
- Immunogen sequence: SFSQP
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It plays a key role in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress. When CHK1 inhibition abrogates the G2 or S checkpoint, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells remain arrested in G1. Therefore, CHK1 is an attractive therapeutic target for cancer treatment, especially in p53-deficient cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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