Thermo Fisher Scientific Cul5 Polyclonal Antibody
Human Cul5 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP 등 다양한 응용에 사용 가능. 고농도(85 mg/mL) 액상 형태로 제공되며, -20°C에서 보관. 인간 및 마우스 Cul5에 반응하며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:500 |
| ELISA | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an N-terminal region near amino acids 1–25 of Human Cul5 (N-terminus) coupled to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 85 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot and freeze at -20°C or below for extended storage.
- Avoid freeze/thaw cycles.
- Centrifuge if not clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody reacts with human Cullin 5. Cross-reactivity is expected against mouse Cul5 based on a high degree of sequence homology. Cross-reactivity with other human cullins may occur.
Target Information
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein, it may contribute to catalysis by positioning the substrate and ubiquitin-conjugating enzyme. The functional specificity of the E3 complex depends on the variable substrate recognition component. ECS(SOCS1) directs ubiquitination of JAK2 and may be involved in proteasomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. It may also form a cell surface vasopressin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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