Thermo Fisher Scientific LGR5 Polyclonal Antibody
LGR5 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Pig 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.0–2.0 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 2–5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to an internal portion of the human GPR49/LGR5 protein (within residues 650–700). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153755 |
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices. They exist in active and inactive forms and signal via G-proteins and downstream effectors.
GPCRs are key targets in pharmacological research, with several blockbuster drugs (e.g., Zyprexa, Claritin) developed as GPCR-targeted therapeutics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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