Thermo Fisher Scientific MEL18 Polyclonal Antibody
Human MEL18 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다. 종양 억제 및 면역 관련 연구에 활용 가능합니다.
- 카탈로그번호
- PA5111259
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human MEL18. Recombinant protein control fragment (Product #RP-100379). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856669 |
Product Specific Information
Immunogen sequence:
SLSIEFYEGA RDRDEKKGPL ENGDGDKEKT GVRFLRCP
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to polycomb group (PcG) gene products. PcG proteins form complexes via protein–protein interactions and maintain transcriptional repression of genes involved in embryogenesis, cell cycle regulation, and tumorigenesis.
This protein acts as a negative regulator of transcription and exhibits tumor suppressor activity. Expression is detected in various tumor cells but limited in neural tissues under normal conditions.
Knockout studies in mice suggest that this protein negatively regulates cytokines, chemokines, and their receptors, playing an important role in lymphocyte differentiation, migration, and immune responses.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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