Thermo Fisher Scientific PPBP Polyclonal Antibody
Human PPBP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% 글리세롤, 0.02% sodium azide) 용액 상태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PPBP. Recombinant protein control fragment (Product # RP-89527) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645805 |
Product Specific Information
Immunogen sequence:
GQTKRNLAKG KEESLDSDLY AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD
Highest antigen sequence identity to the following orthologs:
- Mouse: 47%
- Rat: 47%
Target Information
Members of the α-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a conserved Cys-X-Cys motif and are chemotactic for neutrophils.
The platelet basic protein (PBP), part of this family, is stored in platelet α-granules and released upon activation. Proteolytic cleavage of PBP generates peptides such as mature PBP, connective tissue-activating peptide III (CTAP III or LA-PF4), β-thromboglobulin (β-TG), and neutrophil-activating peptide 2 (NAP-2).
These peptides play roles in inflammation and wound healing, with NAP-2 specifically activating chemotaxis and degranulation in neutrophils.
The human PBP gene is located on chromosome 4q12–q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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