Thermo Fisher Scientific PSMC4 Recombinant Rabbit Monoclonal Antibody (5R9O10)
PSMC4 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, IHC(P), ELISA에 적합하며, 인간, 마우스, 랫트 시료에 반응. HEK293 세포에서 발현된 IgG 형식의 항체로, 고순도 친화 크로마토그래피 정제 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:9,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5R9O10 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–165 of human PSMC4 (NP_006494.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094252 |
Product Specific Information
Immunogen sequence:
MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYA
Target Information
The 26S proteasome is a multicatalytic proteinase complex composed of a 20S core and a 19S regulator. The 20S core contains four rings of 28 non-identical subunits (two alpha and two beta rings). The 19S regulator includes a base with six ATPase and two non-ATPase subunits, and a lid containing up to ten non-ATPase subunits.
Proteasomes degrade peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway and play a key role in MHC class I peptide processing.
The PSMC4 gene encodes one of the ATPase subunits of the 19S regulator, belonging to the triple-A family of ATPases with chaperone-like activity. This subunit interacts with nuclear hormone receptor family members and the liver oncoprotein gankyrin. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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