Thermo Fisher Scientific ATP6AP1 Recombinant Rabbit Monoclonal Antibody (4Z7Q3)
ATP6AP1 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, IHC, ELISA 등 다양한 응용에 적합. 높은 특이성과 재현성을 제공하며, HEK293 발현 시스템을 통해 생산됨. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4Z7Q3 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human ATP6AP1 (NP_001174.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093785 |
Product Specific Information
Immunogen sequence:
MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW SSDRDLWAPA ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE
Target Information
Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP.
A peripheral V1 domain (responsible for ATP hydrolysis) and an integral V0 domain (responsible for proton translocation) compose the V-ATPase.
Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c′, and c″) make up the V0 domain.
ATP6AP1 (ATPase, H⁺ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1, or ATP6IP1, is a type I transmembrane V-ATPase accessory protein predominantly expressed in endocrine and neuronal cells.
ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems. Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain.
Disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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