Thermo Fisher Scientific DLAT Polyclonal Antibody
DLAT 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피 정제. 인간 반응성, 다중 종 예측 반응성. 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:20,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 310–588 of Human DLAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2546519 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2
- Predicted reactivity: Mouse (89%), Rat (87%), Pig (92%), Rhesus Monkey (98%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC).
PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A.
The protein product, dihydrolipoamide acetyltransferase, transfers acetyl groups to coenzyme A.
This protein is the antigen for antimitochondrial antibodies, found in nearly 95% of patients with primary biliary cirrhosis (PBC).
In PBC, activated T lymphocytes attack epithelial cells in the bile duct where DLAT is abnormally distributed and overexpressed, eventually leading to cirrhosis and liver failure.
⚠ WARNING
This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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