Thermo Fisher Scientific Phospho-MAP2K4 (Thr261) Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 MAP2K4 인산화(Thr261) 특이 항체. IHC와 ICC/IF에 사용 가능하며, 권장 희석배수는 각각 1:50–1:100 및 1:100–1:200. 친화 크로마토그래피 정제, PBS/glycerol 버퍼, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine261 (A-K-T(p)-RD) derived from Human SEK1/MKK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554344 |
Product Specific Information
- Suggested positive control for IHC: human breast carcinoma
- Suggested positive control for ICC/IF: HeLa cells
Target Information
MAP2K4 (MEK4) is a serine/threonine kinase belonging to the STE7 family. It phosphorylates and activates JNK1/2 and p38, preferentially targeting tyrosine residues of JNKs. MAP2K4 mediates responses to cellular stress and inflammatory cytokines and plays roles in carcinogenesis. Loss-of-function mutations have been found in lung and pancreatic tumors, while pro-oncogenic roles have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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