Thermo Fisher Scientific SLUG Polyclonal Antibody
Thermo Fisher Scientific의 SLUG Polyclonal Antibody는 인간 및 생쥐 시료에서 SLUG 단백질 검출용으로 최적화된 항체입니다. Western blot과 ELISA에 적합하며, 고순도의 Rabbit IgG로 제작되었습니다. 세포질 및 핵에서의 SLUG 발현 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–150 of human Slug (NP_0030591) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.02 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913667 |
Product Specific Information
- Positive test controls: Mouse spleen, Mouse heart
- Subcellular localization: Cytoplasm, Nucleus
Immunogen sequence:
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS GAYSPITVWT TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH
Target Information
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, is involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Its transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Slug binds E-box regions of promoters and represses transcription of genes like E-cadherin and Claudin-1. Expression of Slug in breast, esophageal, and colorectal carcinomas is correlated with poor prognosis. It also protects hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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