Thermo Fisher Scientific PDE4B Polyclonal Antibody
PDE4B 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | N-terminal peptide unique to PDE4B3 subtype variants |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris glycine, pH 7.4–7.9, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% thimerosal, 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2160812 |
Product Specific Information
PA1-31138 does not cross-react with PDE4B1, PDE4B2, or PDE4B4, nor with PDE4A, PDE4C, or PDE4D.
Predicted molecular weight: 100 kDa.
Target Information
This gene belongs to the type IV cyclic AMP (cAMP)-specific phosphodiesterase (PDE) family.
Cyclic nucleotides act as second messengers in various cellular responses to extracellular signals such as hormones, light, and neurotransmitters. PDE enzymes regulate intracellular cyclic nucleotide levels, influencing signal transduction pathways.
This gene encodes a protein that specifically hydrolyzes cAMP, and altered activity has been linked to schizophrenia and bipolar affective disorder. Multiple splice variants encoding different isoforms have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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