Thermo Fisher Scientific PTX3 Monoclonal Antibody (5B7)
PTX3 단백질을 인식하는 Mouse monoclonal antibody (Clone 5B7). Western blot 및 ELISA에 최적화. Human, Mouse, Rat에 반응. PBS buffer, no preservative. -20°C 보관, 동결/해동 반복 피할 것.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B7 |
| Immunogen | PTX3 (NP_002843, 282 a.a. ~ 380 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SLWVNGELAA TTVEMATGHI VPEGGILQIG QEKNGCCVGG GFDETLAFSG RLTGFNIWDS VLSNEEIRET GGAESCHIRG NIVGWGVTEI QPHGGAQYV
Target Information
Pentraxins are a protein superfamily characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor with a non-redundant role in resistance to selected microbial agents.
Ptx3 belongs to the family of long pentraxins, which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa, and Salmonella typhimurium.
It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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