Thermo Fisher Scientific p53 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (TP53/7002R)

Applications and Tested Dilution

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon activation, p53 induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest.

The p53 protein consists of:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerization domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is critical for p53 activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 plays key roles in preventing proliferation of damaged cells, acting as an anticancer agent, and is involved in aging and oxidative stress responses. Elevated p53 levels have been linked to learning and memory deficits due to effects on long-term potentiation (LTP).

In normal cells, p53 is expressed at very low levels but is upregulated in transformed cell lines, contributing to malignancy. Mutations in the TP53 gene can disrupt DNA binding and abolish tumor suppressor function. Both somatic and germline TP53 alterations are associated with various human cancers, including Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.