Thermo Fisher Scientific AP3M1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 219-418 of human AP3M1 (NP_0362271) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AP3M1,uniProtId:Q9Y2T2-1,ncbiNodeId:9606,antigenRange:219-418,antigenLength:418,antigenImageFileName:PA5-87877_AP3M1_Q9Y2T2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87877_AP3M1_Q9Y2T2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.78 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804474

Product Specific Information

Immunogen sequence: SLSFMNPRLL DDVSFHPCIR FKRWESERVL SFIPPDGNFR LISYRVSSQN LVAIPVYVKH SISFKENSSC GRFDITIGPK QNMGKTIEGI TVTVHMPKVV LNMNLTPTQG SYTFDPVTKV LTWDVGKITP QKLPSLKGLV NLQSGAPKPE ENPSLNIQFK IQQLAISGLK VNRLDMYGEK YKPFKGVKYV TKAGKFQVRT; Positive Samples: 22Rv1, Mouse liver, Mouse kidney, Rat spinal cord, Rat liver; Cellular Location: Cytoplasmic side, Cytoplasmic vesicle membrane, Golgi apparatus, Peripheral membrane protein

Target Information

The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3M1 is highly homologous to AP3M2 but is the preferred binding partner to the YQRL motif from the cytosolic domain of TGN38. AP3M1 has also been shown to interact with the HIV-1 virulence protein Nef.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.