Thermo Fisher Scientific ACVR2A Polyclonal Antibody
ACVR2A 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 사용 가능. 인간과 마우스에 반응하며, Activin/Myostatin 신호전달 연구에 적합. 고순도 정제 및 안정적 PBS buffer 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between amino acids 2–29 from the N-terminal region of human ACVR2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2289142 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, mouse, and rat based on sequence homology.
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
Aliases: ACVR2, ACTRII
These receptors are transmembrane proteins composed of:
- Ligand-binding extracellular domain with cysteine-rich region
- Transmembrane domain
- Cytoplasmic domain with serine/threonine kinase activity
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
Upon ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors.
Type II receptors are constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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