Thermo Fisher Scientific GAPVD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GAPVD1 for IHC and ICC/IF applications. Recognizes recombinant GAPVD1 protein with high specificity. Suitable for endocytosis and receptor trafficking studies. Provided in liquid form, purified by antigen affi...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GAPVD1. Recombinant protein control fragment (Product #RP-93045). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641865 |
Product Specific Information
Immunogen sequence:
SSLDLEGESV SELGAGPSGS NGVEALQLLE HEQATTQDNL DDKLRKFEIR DMMGLTDDRD ISETVSETWS TDVLGSDFDP NIDEDRLQEI AGAAAENMLG SLLCLPGSGS VLL
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), participating in processes such as endocytosis, insulin receptor internalization, and LC2A4/GLUT4 trafficking. It acts as a GEF for RAB31 by exchanging GDP for GTP, regulating LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state, retaining LC2A4/GLUT4 inside cells. Upon insulin stimulation, GAPVD1 translocates to the plasma membrane, releasing LC2A4/GLUT4 from intracellular vesicles. It also contributes to EGFR trafficking and degradation, possibly by promoting ubiquitination and proteasomal degradation. GAPVD1 exhibits GEF activity for Rab5 and GAP activity for Ras.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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