Thermo Fisher Scientific Phospho-c-Cbl (Tyr700) Recombinant Rabbit Monoclonal Antibody (CblY700-E1)
Phospho-c-Cbl (Tyr700) 특이적 recombinant rabbit monoclonal antibody로, 인간·마우스·랫트 반응성. HEK293 발현 시스템 기반, Protein A/G 정제. PBS/glycerol buffer에 보관, -20°C 저장. 연구용 세포 신호전달 연구에 적합.
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Thermo Fisher Scientific Phospho-c-Cbl (Tyr700) Recombinant Rabbit Monoclonal Antibody (CblY700-E1)
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–1,000 ng/mL
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CblY700-E1 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr700 of human phospho c-Cbl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol, 0.10% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897285 |
Additional Formats
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed. Cbl-c can ubiquitinate activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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