Thermo Fisher Scientific Phospho-c-Cbl (Tyr700) Recombinant Rabbit Monoclonal Antibody (CblY700-E1), PE
PE 형광 표지된 인산화 c-Cbl (Tyr700) 특이 재조합 단클론 항체로, 인간·마우스·랫트 시료에 반응. Flow Cytometry에 적합하며, 고순도 Protein A/G 정제. 연구용으로 세포 신호 조절 및 EGFR 분해 연구에 활용 가능.
- 카탈로그번호
- MA537352
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-c-Cbl (Tyr700) Recombinant Rabbit Monoclonal Antibody (CblY700-E1), PE
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CblY700-E1 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr700 of human phospho c-Cbl |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897286 |
Additional Formats
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c can ubiquitinate activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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