Thermo Fisher Scientific MSK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MSK1, validated for WB and IHC(P). Detects non-phosphorylated MSK1 around Ser360. Supplied as liquid at 1 mg/mL, stored at -20°C. For research use only.
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- PA538369
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic non-phosphopeptide derived from human MSK1 around the phosphorylation site of Ser360 (T-Y-SP-P-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554970 |
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase essential for regulating various cellular processes. It mediates mitogen- or stress-induced phosphorylation of transcription factors such as CREB1 and ATF1, and regulates RELA, STAT3, and ETV1/ER81, contributing to gene activation via histone phosphorylation.
MSK1 plays a key role in inflammatory gene regulation and RELA transcriptional control in response to TNF and glucocorticoids. It associates with the glucocorticoid receptor NR3C1 to repress inflammatory gene expression. In skeletal myoblasts, it phosphorylates RELA at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it is required for STAT3 Ser-727 phosphorylation and transcriptional regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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