Thermo Fisher Scientific FOXO4 Polyclonal Antibody
FOXO4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 적합하며, 인간·마우스·랫트 반응성. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 1 mg/mL 농도 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10–20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the amino terminus of human FOXO4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154561 |
Product Specific Information
A suggested positive control is A-20 cell lysate.
PA5-20975 can be used with blocking peptide PEP-1089.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. Also known as AFX1 or MLLT7, it belongs to the O class of forkhead/winged helix family transcription factors, along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of Akt, another downstream target, leads to phosphorylation of FOXO4 on specific Ser/Thr residues, mediating its binding to 14-3-3 and subsequent nuclear export.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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