Thermo Fisher Scientific POLD3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human POLD3 protein. Validated for IHC (P) and ICC/IF applications. High specificity and affinity purified via antigen affinity chromatography. Supplied in PBS with 40% glycerol for stable storage. For research use ...
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- PA563618
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLD3. Recombinant protein control fragment (Product #RP-103343). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645745 |
Product Specific Information
Immunogen sequence:
SVTEPKLATP AGLKKSSKKA EPVKVLQKEK KRGKRVALSD DETKETENMR KKRRRIKLPE SDSSEDEVFP DSPGAY
Highest antigen sequence identity to orthologs:
- Mouse: 75%
- Rat: 75%
Target Information
DNA replication, recombination, and repair — all essential for genomic stability — require exonucleases. During DNA replication, exonucleases process Okazaki fragments; in DNA repair, they excise damaged DNA and correct recombinational mismatches. These functions involve DNA polymerase families (alpha, beta, delta, epsilon). DNA polymerase delta and epsilon are multisubunit enzymes; DNA polymerase delta consists of two subunits interacting with the sliding clamp protein PCNA. DNA polymerase delta 3 (POLD3 or p66) is a 466 amino acid nuclear protein required for proper DNA polymerase delta function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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