Thermo Fisher Scientific P2X2 Polyclonal Antibody
Rabbit polyclonal antibody targeting rat P2X2 receptor (aa 457–472). Validated for WB, IHC(F), ICC/IF, and IP assays. Lyophilized form, 0.8 mg/mL concentration, stored at -20°C. Suitable for research use in neuronal and smooth muscle ATP-mediated synap...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Frozen) (IHC(F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)SQQDSTSTDPKGLAQL, corresponding to amino acid residues 457–472 of rat P2X2 receptor |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736291 |
Product Specific Information
- Shipped at room temperature as a lyophilized powder.
- Store at -20°C upon receipt.
- Reconstitute in 50 µL of deionized water before use.
Target Information
P2rx2 belongs to the ligand-gated ion channel family activated by extracellular ATP. Each receptor is a trimer composed of subunits (P2X1–7) sharing two transmembrane domains. P2rx2 mediates synaptic transmission between neurons and neurons to smooth muscle, influencing sensory neuron responses, NMJ formation, hearing, taste perception, and peristalsis.
In the inner ear, P2rx2 regulates sound transduction, auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K⁺ recycling.
Diseases associated with P2RX2 include Autosomal Dominant Deafness 41 and DFNA41 Nonsyndromic Hearing Loss and Deafness.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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