Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1C4), TrueMAB
TYMS 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 인간 반응성, 무보존제 PBS 버퍼 기반, 동결건조 형태로 제공됩니다. DNA 합성 관련 연구 및 항암제 반응 분석에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C4 |
| Immunogen | Full length human recombinant protein of human TYMS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Thymidylate Synthase (TS) catalyzes conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis.
TS is a key target for fluoropyrimidine-based antineoplastic drugs used in solid tumor treatments.
5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS via covalent complex formation with the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS correlates with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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