Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1C4), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Thymidylate Synthase (TS) catalyzes conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis.
TS is a key target for fluoropyrimidine-based antineoplastic drugs used in solid tumor treatments.
5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS via covalent complex formation with the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS correlates with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.