Thermo Fisher Scientific DUSP1 Polyclonal Antibody
DUSP1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간, 생쥐, 랫트 시료에 반응. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 -20°C에서 보관.
- 카탈로그번호
- TA890036
- 판매단위
- pk
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Thermo Fisher Scientific DUSP1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human DUSP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.47 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein structurally similar to non-receptor-type protein-tyrosine phosphatases and shares significant amino acid sequence similarity with a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.
The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, specifically inactivating mitogen-activated protein (MAP) kinase in vitro by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts.
Therefore, DUSP1 may play an important role in the human cellular response to environmental stress and in the negative regulation of cellular proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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