
Thermo Fisher Scientific CBX5 Polyclonal Antibody
Human CBX5(HP1 alpha) 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 시약이며, 4°C에서 보관. 유전자 발현 및 염색질 구조 연구용으로 사용.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and the C-terminus (residue 191) of human Chromobox Homolog 5 (HP1 alpha, UniProt ID: P45973-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 50 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, mediating gene silencing. Mammalian methyltransferases that methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, which are adaptor molecules involved in gene silencing and chromatin structure. The HP1 chromodomain specifically recognizes methylated histone H3 at lysine-9. In Suv39h double knockout mouse fibroblasts, HP1 association with heterochromatin is lost but restored upon reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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