Thermo Fisher Scientific ICAM1 Monoclonal Antibody (OTI1E5), TrueMAB
인간 ICAM1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. TrueMAB 포맷으로 높은 특이성과 재현성을 제공. 액상 형태이며 1 mg/mL 농도로 PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E5 |
| Immunogen | Full length human recombinant protein of human ICAM1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein composed of five extracellular immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain. It has seven potential N-linked glycosylation sites and shares sequence homology with ICAM-2 (CD102) and ICAM-3 (CD50).
ICAM-1 binds to integrins such as CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for Rhinovirus. It is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils. Expression increases under inflammatory conditions, and soluble ICAM-1 is detectable in plasma of patients with inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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