Thermo Fisher Scientific BUBR1 Recombinant Rabbit Monoclonal Antibody (23GB1640)
Thermo Fisher의 BUBR1 Recombinant Rabbit Monoclonal Antibody (23GB1640)는 인간 BUBR1 단백질을 타겟으로 하는 고특이성 항체로, WB·ICC·Flow Cytometry에 적합합니다. HEK293F 발현 시스템에서 생산되며, 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1640 |
| Immunogen | A synthesized peptide derived from human BubR1 (600–650AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Defects in spindle checkpoints can lead to genetic instability and promote malignant transformation.
Human cells express two related checkpoint kinases derived from the BUB1 gene: hBUBR1 and hBUB1. These kinases monitor mitotic kinetochore-microtubule interactions and are essential for proper mitotic progression, preventing premature entry into anaphase.
BUBR1 has been detected in various human cancers and identified as a binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which may accelerate breast cancer progression by compromising mitotic checkpoint control through BUBR1 inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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