Thermo Fisher Scientific Phospho-CDK9 (Thr186) Polyclonal Antibody
CDK9 단백질의 Thr186 인산화 부위를 인식하는 rabbit polyclonal antibody입니다. Western blot에 적합하며 인간, 마우스, 랫트 등 다양한 종에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pThr186 of human CDK9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 126 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982053 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CDK9 is a serine/threonine kinase which, when complexed with CyclinT1, forms an active holoenzyme complex that regulates the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors. It promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement, leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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