Thermo Fisher Scientific KLRB1 Monoclonal Antibody (OTI5F10), TrueMAB
인간 KLRB1 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합. 무보존제, 동결건조 형태로 제공되며 1 mg/mL 농도. NK 세포 및 T 세포 표면 항원 연구용으로 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific KLRB1 Monoclonal Antibody (OTI5F10), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 67–225 of human KLRB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
KLRB1 (CD161) is a type II membrane protein expressed on nearly all NK cells and a subset of CD3⁺ T cells.
It forms a homodimeric cell surface structure (40–44 kDa) and plays an inhibitory role in NK cell activity.
Activation of KLRB1 stimulates acid sphingomyelinase/SMPD1, increases intracellular ceramide, and activates AKT1/PKB and RPS6KA1/RSK1 kinases.
KLRB1 acts as a lectin binding to Gal-α(1,3)Gal and N-acetyllactosamine epitopes, and interacts with CLEC2D/LLT1 to inhibit NK cell cytotoxicity and IFN-γ secretion.
The protein includes extracellular C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.