Thermo Fisher Scientific RHEBL1 Polyclonal Antibody
RHEBL1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 보관. 인간 시료에 반응하며 연구용으로 적합.
- 카탈로그번호
- PA563919
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RHEBL1 Polyclonal Antibody
Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RHEBL1. Recombinant protein control fragment (Product # RP-101851) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2646534 |
Product Specific Information
Immunogen sequence:
SSARENQLTQ GIFTKVIQEI ARVENSYGQE RRCHLM
Highest antigen sequence identity:
- Mouse: 81%
- Rat: 81%
Target Information
RhebL1 (ras homolog enriched in brain-like protein 1), also known as Rheb2 or GTPase RhebL1, is a 183 amino acid protein belonging to the small GTPase superfamily and Rheb family.
It localizes to the cell membrane and cytoplasm, is ubiquitously expressed, and shows increased expression in many tumor cell lines.
RhebL1 exhibits GTPase activity, may activate NF-kappa-B-mediated gene transcription, and regulates Rictor activity to promote signal transduction.
It exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 12q13.12 and mouse chromosome 15 F1.
Human chromosome 12 encodes over 1,100 genes and represents approximately 4.5% of the human genome, associated with various disorders such as hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome, and trisomy 12p.
Functional characteristics:
- Binds GTP and exhibits intrinsic GTPase activity
- Activates NF-kappa-B-mediated gene transcription
- Promotes signal transduction through MTOR and activates RPS6KB1
- Acts downstream of TSC1 and TSC2
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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