Thermo Fisher Scientific RHEBL1 Polyclonal Antibody

Applications

Tested Applications and Dilutions

• Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
SSARENQLTQ GIFTKVIQEI ARVENSYGQE RRCHLM

Highest antigen sequence identity:

• Mouse: 81%
• Rat: 81%

Target Information

RhebL1 (ras homolog enriched in brain-like protein 1), also known as Rheb2 or GTPase RhebL1, is a 183 amino acid protein belonging to the small GTPase superfamily and Rheb family.
It localizes to the cell membrane and cytoplasm, is ubiquitously expressed, and shows increased expression in many tumor cell lines.
RhebL1 exhibits GTPase activity, may activate NF-kappa-B-mediated gene transcription, and regulates Rictor activity to promote signal transduction.
It exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 12q13.12 and mouse chromosome 15 F1.
Human chromosome 12 encodes over 1,100 genes and represents approximately 4.5% of the human genome, associated with various disorders such as hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome, and trisomy 12p.

Functional characteristics:

• Binds GTP and exhibits intrinsic GTPase activity
• Activates NF-kappa-B-mediated gene transcription
• Promotes signal transduction through MTOR and activates RPS6KB1
• Acts downstream of TSC1 and TSC2

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.