Thermo Fisher Scientific NARF Polyclonal Antibody
Thermo Fisher Scientific의 NARF Polyclonal Antibody는 인간 NARF 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 ICC/IF에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 40% 글리세롤이 포함되어 장기 보관이 용이합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human NARF. Recombinant protein control fragment (Product # RP-104958) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665080 |
Product Specific Information
Immunogen sequence:
KTDDQENVSAD APSPAQENGE KGEFHKLADA KIFLSDCLAC DSCMTAEEGV QLSQQNAKDF FRVLNLNKKC DTSKHKVLVV SVCPQSLPYF AAKFNLSVTD ASRRLCGFLK SLG
Highest antigen sequence identity to the following orthologs:
- Mouse: 84%
- Rat: 93%
Target Information
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment; however, it also plays a role in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A and B-type lamins.
Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This modified cysteine residue is removed from prelamin A when it is processed into mature lamin A.
The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain and may be a component of a prelamin A endoprotease complex. It is located in the nucleus, partially colocalizing with the nuclear lamina, and shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon generated by RNA editing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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