Thermo Fisher Scientific IFIT5 Polyclonal Antibody
IFIT5 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 면역세포염색(ICC/IF)에 사용 가능. 인간 시료에 반응하며, 고순도의 액상 형태로 제공. 항바이러스 반응 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IFIT5 (Accession Q13325), corresponding to amino acid residues E170–F220 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854468 |
Product Specific Information
Antibody detects endogenous levels of total IFIT5.
Target Information
Interferon-induced RNA-binding protein involved in the human innate immune response.
Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense.
Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268).
Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs.
Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection.
Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420).
Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268).
Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by synergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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