Thermo Fisher Scientific IFIT5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total IFIT5.

Target Information

Interferon-induced RNA-binding protein involved in the human innate immune response.
Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense.
Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268).
Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs.
Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection.
Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420).
Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268).
Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by synergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.