Thermo Fisher Scientific IL18BP Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total IL18BP.

Target Information

Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors. Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity.

As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to diseases such as eczema, asthma, and Crohn’s disease. Upregulation of IL-18BP by keratinocytes expressing HPV E7 oncoprotein decreases IL-18-induced IFN-gamma production and T cell activation. Elevated levels of IL-18 and IL-18BP, along with proinflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta, and IL-8, have been observed in macrophages from Crohn’s disease lesions and intestinal tissues.

IL-18BP belongs to the immunoglobulin-like receptor class, containing a single Ig domain. Two of the four human isoforms (b and d) have incomplete domains that reduce binding affinity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.