Thermo Fisher Scientific BMP2 Monoclonal Antibody (3G7)
BMP2 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody(3G7)로, ELISA에 적합합니다. 인간 BMP2에 반응하며, 비결합형 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, PBS(pH 7.4)에 보존제 없이 제공됩니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G7 |
| Immunogen | BMP2 (NP_001191, 283 a.a. ~ 396 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
QAKHKQRKRL KSSCKRHPLY VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
Target Information
Bone Morphogenic Proteins (BMPs) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998, Francis-West et al. 1999).
Mature BMPs (30–38 kDa) assume a TGF-beta-like cysteine knot configuration. Lovostatin increases bone formation by activating the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and influence stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997).
They also play important roles in visceral development, cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999).
BMPs contribute to dorsal/ventral patterning and, like TGF-beta, bind to a type II receptor that recruits a type I receptor unit, activating the Smad signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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